Postdoctoral Position is available immediately at the University of California, Los Angeles (UCLA) in the laboratory of Professor Rhonda Voskuhl, President of the OSSD. The Voskuhl lab studies sex differences in health and disease. The diseases of interest encompass multiple sclerosis, Alzheimer’s disease, and cognitive decline with brain aging, including menopause. The role of sex chromosomes are studied using the Four Core Genotype mice as well as cell-specific conditional knockouts X chromosome genes (such as Kdm6a) within the brain. Effects of sex chromosome manipulations are measured using RNA-sequencing in a cell-specific and region-specific manner to determine how sex affects regional gene expression in astrocytes, microglia, oligodendrocytes, and neurons. This reveals novel therapeutic targets, which are then tested to reverse cell-specific and region-specific gene expression and to repair deleterious phenotypes of neurodegeneration. The role of sex hormones focuses on estrogens, namely estrogen receptor beta ligand treatments in mice with selective deletion of ER-beta in a target brain cell of interest, with subsequent assessment of effect on phenotype (behavioral testing and double-label immunohistochemistry). Other novel treatments focusing on sex differences in mitochondrial function during health and disease hold potential. The individual must have excellent oral and written English language skills with either a Ph.D., M.D., or both. Ideally, the candidate currently resides within the U.S. The lab environment will be one of creative independence on a primary project complemented by contributions to others projects through a collaborative team approach with those in the lab doing neurogenetics, neuropathology, and neuroimaging.
The position is for 1-2 years and is renewable, depending on progress, for up to 3 additional years. Salary and benefits are in accord with University of California guidelines, which consider cost of living in this highly desirable location. UCLA is in Westwood, a university “village”, nestled between Beverly Hills on the east, Bel Air on the north, and Santa Monica and the beach on the west. Please submit a CV (including 2 references with contacts) and a cover letter of research interests currently as well as areas of possible focus for a future project based on areas of interest of the Voskuhl lab
See publications link: https://www.ncbi.nlm.nih.gov/pubmed/?term=((rhonda+voskuhl%5BAuthor%5D)+OR+Voskuhl+RR%5BAuthor%5D)+OR+voskuhl+r%5BAuthor%5D
Submit to: [email protected]
Rhonda Voskuhl, M.D.
Jack H. Skirball Chair
Professor, UCLA Dept. of Neurology
Director, UCLA Multiple Sclerosis Program
Laurie D. and Steven C. Gordon Neuroscience Research Building
635 Charles E. Young Drive South
Los Angeles, CA 90095